NODES 2025 - Knowledge Combined Common Data Model: A Graph-Based Integration of Reactome and OMOP CDM

Although clinical databases capture patient phenotypes and treatments, they often lack direct connections to the underlying biological pathways that drive disease processes and therapeutic responses. We developed a unified graph structure by integrating two complementary knowledge sources—the Reactome pathway database and the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM) containing MIMIC-IV clinical data. We expect that this integrated graph structure provides a foundation for mechanistic interpretation of clinical outcomes by connecting patient-level observations to underlying biological processes. Speaker: Sungjae Jung Resources: Get Started with Aura - https://bit.ly/3LOLrjh Deployment Center - https://bit.ly/4jOelM3 Ground AI Systems and Agents with Neo4j - https://bit.ly/4oVsnyb #nodes2025 #neo4j #graphdatabase #graphrag #knowledgegraph