MIT 7.91J Foundations of Computational and Systems Biology - 5. Library Complexity and Short Read Alignment (Mapping)

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27.5 hours of video
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Summary

Keywords

7-91j-foundations-of-computational-and-systems-biology-spring-2014 burrows-wheeler transform bwt dna sequencing full-text minute-size index genome library complexity poisson read mapping sequencing adapter short read alignment

Full Transcript

MIT 7.91J Foundations of Computational and Systems Biology, Spring 2014 View the complete course: http://ocw.mit.edu/7-91JS14 Instructor: David Gifford Prof. Gifford talks about library complexity as it relates to genome sequencing. He explains how to create a full-text minute-size (FM) index, which involves a Burrows-Wheeler transform (BWT). He ends with how to deal with the problem of mismatching. License: Creative Commons BY-NC-SA More information at http://ocw.mit.edu/terms More courses at http://ocw.mit.edu

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