Emergency Medicine & Critical Care - Hereditary Angioedema (HAE)

😍🖼Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/ - With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep... Disclaimer: I use affiliate links.... ►👨‍🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Hereditary angioedema (HAE) is an autosomal dominant disorder characterized by a deficiency (or dysfunction) of the C1 esterase inhibitor (C1INH) leading to release of inhibition of plasma kallikrein which increases plasma bradykinin level. Hereditary angioedema (HAE) causes increases bradykinin causing angioedema, dry cough, abdominal pain, ...etc. Bradykinin is produced from high molecular weight kininogen (HMWK) via plasma kallikrein. High molecular weight kininogen is a plasma protein (alpha globulin) responsible for activating the intrinsic coagulation pathway as well as producing the inflammatory mediator known as bradykinin (via plasma kallikrein). Plasma kallikrein, in addition to high molecular weight kininogen (HMWK), is responsible for activating factor XII into XIIa. Kallikrein-Kinin system consists of a kallikrein (plasma kallikrein or tissure kallikrein) producing a kinin (bradykinin in the plasma and kallidin in the tissue). Angiotensin-converting enzyme (ACE) degrades bradykinin into inactive metabolites. Get all of my illustrated notes shown in my videos + 50 hematology cases here: https://www.patreon.com/medicosis/ Check my full playlist on "bleeding and coagulation" here: https://goo.gl/Dt41Bg ► If you love MNEMONICS, check out this amazing website https://www.picmonic.com/referrals/JK55NQXQQB9JLA219 ► Sign up for Dropbox for FREE: https://db.tt/IIlB8ejxWe *** As a small gift for my viewers, here are 2 FREE audiobooks from Audible https://amzn.to/2FQurW0 Learning has never been easier. *** Also, try Amazon Kindle unlimited for FREE, they have some good medical books that you can read for FREE. https://amzn.to/2UceoG2 Books that I use for this series: ► Guyton and Hall Medical Physiology Textbook https://goo.gl/yZoeS9 ► Goljan Rapid Review Pathology, https://amzn.to/2MufTPw ► Harrison’s Internal Medicine https://amzn.to/2OJiVNf ► Goldman-Cecil Medicine https://amzn.to/2N0v93u ► Davidson’s Principles and Practice of Medicine https://amzn.to/2vTmf1p In brief, hereditary angioedema (HAE) is an autosomal dominant disorder having a deficiency of C1 inhibitor (C1INH) causing increased bradykinin leading to angioedema, laryngeal edema, cough, abdominal pain, hypotension,...etc. ACE inhibitors are contraindicated. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/ ► Visit my website: https://www.medicosisperfectionalis.com/ My Favorite Productivity App: https://airtable.com/invite/r/2zH40fus/ 📱Save on your mobile phone bill: http://fbuy.me/q6bMj 🏦 Qbank (TrueLearn): https://truelearn.referralrock.com/l/MEDICOSIS/